Evaluation to population genetics data Assignment

Evaluation to population genetics data - Assignment Example The genetic variants identified accounted for small part of heritability. The genome wide association of the wider sample was used to determine the remaining data set. The small part of the unrelated gene shows the proportion of the total variance in the polymorphism. Allele frequency was calculated by power stats v 12 application. Hardy Weinberg equilibrium was analyzed using the Chi square x2. Significance level was 0.05 in all the 15 Loci. The sampled population was compared to Turkey, Iraq Iranian, Pakistan and Russian populations. The Fst values were calculated and Bonferroni correction test done in order to confirm the significant differences in the analysis. The estimated haplotypes frequencies from the data show there is 56 haplotypes and estimated 107 with no missing genotypes. The estimated result show haplotype frequencies are identical. Implementation of Stephen Al’s Bayesian method is used since the haplotype frequencies is not to be included in the reporting phase.(Czarny 2005). The analyzed genotype showed that data sets with 200 subjects and 132 STRs contained in one gene. Allelic diversity which provides unbiased estimates of the expected heterozygote frequency was computed. The genotype data was used to estimate the power of discrimination (Pakstis&Castiglione 1997).Allele frequencies distribution for 15 PCR based Loci D8S1179, D21S11, D7S820, CSFIPO, D3S1358, TH01, D13S137, D16S539, D2S1338, D19S433, vWA, TPOX, D18S51, D5S818, FGA) for a sample of 200 unrelated individuals as it shows in the table below. The observed allele frequencies and statistical parameters based on the 15STR as summarized in the above table show allelic frequencies ranging from 0.0021 to 0.4077 with number of alleles ranging from 6 (THO1, TPOX and D5S818) to 17 (D21S11, D18S51 and FGA). The 15 STR are highly polymorphic. The new allele is underlined while most common alleles are indicated