Curcumin to cure Cancer Research Paper Example | Topics and Well Written Essays - 500 words

Curcumin to cure Cancer - Research Paper Example ies have been performed that hold up curcumin-mediated regulation of COX pathways, which is an essential mechanism by which curcumin stops a number of ailment processes, including the cancer. The precise regulation of COX-2 by curcumin is not fully established; though, existing evidence show that curcumin controls COX-2 mainly at the transcriptional level and, to some extent, the posttranslational level. The curcumin-selective transcriptional control action of the COX-2 inhibitory potential of this naturally occurring agent offer unique advantages over synthetic COX inhibitors, such as non-steroidal anti-inflammatory drugs. Cells will be treated with free Cisplatin and then with free curcumin to test the effectiveness of the chemotherapeutic drug. This control will be compared to a plate of cells treated with nano-encapsulated curcumin along with cisplatin. My hypothesis is that the nanoparticle delivery of drugs will show less resistance in the cells to the chemopreventive drug, a down regulation of COX-2, as well as decreased proliferation. I will be using fluorescent mesoporous  silica  nanoparticles to encapsulate the cisplatin and deliver it to the mitochondria of the cells. The delivery system should not only demonstrate enhanced cellular uptake, but also show an elevated  drug effect which should reduce the associated side effects. In addition, a new, simple and reasonably priced fluorescent based PT quantification technique has been adopted as an alternative of the commonly used ICP-based quantification method and this strategy of quantification could be elaborated to monitor fluorescentà ‚  pro drug  nanoparticles  during real-time diagnosis. A common problem with the present chemotherapeutic interventions is that it causes inflammation in the gut and kidney cells. To test my method against this, I will also conjugate the cisplatin nanoparticles with curcumin to test if the side effects are even further diminished. To measure the effectiveness of the